TY - BOOK AU - Halloran,M.Elizabeth AU - Longini,Ira M. AU - Struchiner,Claudio J. TI - Design and analysis of vaccine studies T2 - Statistics for biology and health, SN - 9780387403137 (alk. paper) AV - QR189 .H35 2010 U1 - 615/.372072 23 PY - 2010/// CY - New York PB - Springer KW - Vaccines KW - Research KW - Statistical methods KW - Epidemiology KW - Case-control method KW - Research Design KW - Clinical Trials as Topic KW - Drug Evaluation KW - methods KW - Statistics as Topic N1 - Includes bibliographical references (p. 361-379) and index; Overview of vaccine effects and study designs -- Immunology and early phase trials -- Binomial and stochastic transmission models -- R[o] and deterministic models -- Evaluating protective effects of vaccination -- Models of action and time-varying VE[s] -- Further evaluation of protective effects -- Vaccine effects on post-infection outcomes -- Household-based studies -- Analysis of households in communities -- Analysis of independent households -- Assessing indirect, total, and overall effects -- Randomization and baseline transmission -- Surrogates of protection ER -