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  <titleInfo>
    <title>Design and analysis of vaccine studies</title>
  </titleInfo>
  <name type="personal">
    <namePart>Halloran, M. Elizabeth.</namePart>
    <role>
      <roleTerm authority="marcrelator" type="text">creator</roleTerm>
    </role>
  </name>
  <name type="personal">
    <namePart>Longini, Ira M.</namePart>
  </name>
  <name type="personal">
    <namePart>Struchiner, Claudio J.</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
  <genre authority="marc">bibliography</genre>
  <originInfo>
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    <place>
      <placeTerm type="text">New York</placeTerm>
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    <publisher>Springer</publisher>
    <dateIssued>c2010</dateIssued>
    <dateIssued encoding="marc">2010</dateIssued>
    <issuance>monographic</issuance>
  </originInfo>
  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
  </language>
  <physicalDescription>
    <form authority="marcform">print</form>
    <extent>xviii, 387 p. : ill. ; 24 cm.</extent>
  </physicalDescription>
  <tableOfContents>Overview of vaccine effects and study designs -- Immunology and early phase trials -- Binomial and stochastic transmission models -- R[o] and deterministic models -- Evaluating protective effects of vaccination -- Models of action and time-varying VE[s] -- Further evaluation of protective effects -- Vaccine effects on post-infection outcomes -- Household-based studies -- Analysis of households in communities -- Analysis of independent households -- Assessing indirect, total, and overall effects -- Randomization and baseline transmission -- Surrogates of protection.</tableOfContents>
  <note type="statement of responsibility">M. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner.</note>
  <note>Includes bibliographical references (p. 361-379) and index.</note>
  <subject authority="lcsh">
    <topic>Vaccines</topic>
    <topic>Research</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Vaccines</topic>
    <topic>Statistical methods</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Epidemiology</topic>
    <topic>Research</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Case-control method</topic>
  </subject>
  <subject authority="mesh">
    <topic>Research Design</topic>
  </subject>
  <subject authority="mesh">
    <topic>Vaccines</topic>
  </subject>
  <subject authority="mesh">
    <topic>Clinical Trials as Topic</topic>
  </subject>
  <subject authority="mesh">
    <topic>Drug Evaluation</topic>
    <topic>methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Research</topic>
    <topic>methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Statistics as Topic</topic>
  </subject>
  <classification authority="lcc">QR189 .H35 2010</classification>
  <classification authority="ddc" edition="23">615/.372072</classification>
  <classification authority="nlm">2010 K-719</classification>
  <classification authority="nlm">QW 805</classification>
  <relatedItem type="series">
    <titleInfo>
      <title>Statistics for biology and health</title>
    </titleInfo>
  </relatedItem>
  <identifier type="isbn">9780387403137 (alk. paper)</identifier>
  <identifier type="isbn">0387403132 (alk. paper)</identifier>
  <identifier type="isbn">9780387686363 (eISBN)</identifier>
  <identifier type="isbn">0387686363 (eISBN)</identifier>
  <identifier type="lccn">2009938829</identifier>
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