02140cam a22004934a 450000100090000000300040000900500170001300800410003001000170007101500190008801600200010701600180012702000310014502000280017602000260020402000230023003500240025304000520027704200080032905000210033706000150035806000110037308200200038410000280040424501130043226000340054530000360057949000500061550400640066550505760072965000240130565000350132965000280136465000250139265000210141765000140143865000300145265000300148265000230151265000250153570000200156070000270158083000390160715936302OSt20150408114105.0091008s2010    nyua     b    001 0 eng c  a  2009938829  aGBA9943512bnb7 a1015396782DNLM7 a0153804412Uk  a9780387403137 (alk. paper)  a0387403132 (alk. paper)  a9780387686363 (eISBN)  a0387686363 (eISBN)  a(OCoLC)ocn436030925  aNLMcNLMdUKMdBTCTAdOHXdCDXdYDXCPdMMUdDLC  apcc00aQR189b.H35 201000a2010 K-71910aQW 80500a615/.3720722231 aHalloran, M. Elizabeth.10aDesign and analysis of vaccine studies /cM. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner.  aNew York :bSpringer,cc2010.  axviii, 387 p. :bill. ;c24 cm.1 aStatistics for biology and health,x1431-8776  aIncludes bibliographical references (p. 361-379) and index.0 aOverview of vaccine effects and study designs -- Immunology and early phase trials -- Binomial and stochastic transmission models -- R[o] and deterministic models -- Evaluating protective effects of vaccination -- Models of action and time-varying VE[s] -- Further evaluation of protective effects -- Vaccine effects on post-infection outcomes -- Household-based studies -- Analysis of households in communities -- Analysis of independent households -- Assessing indirect, total, and overall effects -- Randomization and baseline transmission -- Surrogates of protection. 0aVaccinesxResearch. 0aVaccinesxStatistical methods. 0aEpidemiologyxResearch. 0aCase-control method.12aResearch Design.12aVaccines.22aClinical Trials as Topic.22aDrug Evaluationxmethods.22aResearchxmethods.22aStatistics as Topic.1 aLongini, Ira M.1 aStruchiner, Claudio J. 0aStatistics for biology and health,