Design and analysis of vaccine studies /
M. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner.
- New York : Springer, c2010.
- xviii, 387 p. : ill. ; 24 cm.
- Statistics for biology and health, 1431-8776 .
- Statistics for biology and health, .
Includes bibliographical references (p. 361-379) and index.
Overview of vaccine effects and study designs -- Immunology and early phase trials -- Binomial and stochastic transmission models -- R[o] and deterministic models -- Evaluating protective effects of vaccination -- Models of action and time-varying VE[s] -- Further evaluation of protective effects -- Vaccine effects on post-infection outcomes -- Household-based studies -- Analysis of households in communities -- Analysis of independent households -- Assessing indirect, total, and overall effects -- Randomization and baseline transmission -- Surrogates of protection.
Vaccines--Research. Vaccines--Statistical methods. Epidemiology--Research. Case-control method. Research Design. Vaccines. Clinical Trials as Topic. Drug Evaluation--methods. Research--methods. Statistics as Topic.