Machine generated contents note: Chapter 1.) Clinical Development and Statistics: The General View Chapter 2.) Questions when Planning Trials Chapter 3.) Medical Product Attributes Chapter 4.) Setting Research Objectives Chapter 5.) Statistical Thinking Chapter 6.) Estimation Chapter 7.) From Description to Testing: A Beginning Chapter 8.) Statistical Significance, Explanation and Prediction Chapter 9.) Exploratory and Confirmatory Clinical Trials Chapter 10.) One, Two, Three Testing: Hypothesis Testing and Multiplicity Chapter 11.) Elements of Clinical Trial Design I: Putting it together Chapter 12.) Elements of Clinical Trial Design II Chapter 13.) Choosing Trial Endpoints Chapter 14.) Determination of Sample Size Chapter 15.) Concluding Remarks.